Paul D. Drew, Ph.D.

DrewPositions

Professor and Vice Chair, Department of Neurobiology and Developmental Sciences

Contacts

E-mail: drewpauld@uams.edu

Research Experience

I received my Ph.D. in Zoology (Cell and Molecular Biology) from the University of Maryland. Dr. Drew received postdoctoral training in the Neuroimmunology Branch of the National Institute of Neurological Diseases and Stroke, National Institutes of Health. My work at NIH focused on neuroinflammatory and neurodegenerative disorders with a focus on multiple sclerosis. I joined the faculty at UAMS in 1996 where he has continued his MS research. More recently, in collaboration with Dr. Cindy Kane at UAMS, my research has focused on the role of alcohol-induced neuroinflammation in driving neurodegeneration. These studies are highly relevant to developmental disorders including fetal alcohol spectrum disorders as well as alcohol use disorders and alcohol addiction in adolescents and adults.  My research has been steadily funded by the National Institutes of Health, the National Science Foundation, and private agencies.

Recent Publications

Solt, L.A., N. Kumar, P. Nuhant, Y. Wang, J.L. Lauer, J. Liu, M.A. Istrate, T.M. Kamenecka, W. R. Roush, D. Vidovic, S. C. Schurer, J. Xu, G. Wagoner, P.D. Drew, P. R. Griffin, and T.P. Burris. 2011. Inhibition of T(H)17 differentiation and suppression of autoimmunity by a selective ROR ligand. Nature. 472:491-494.

Kane, C.J.M., K.D. Phelan, L. Han, R.R. Smith, J. Xie, J.C. Douglas, and P.D. Drew. 2011. Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator activated receptor gamma ligands. Brain Behavior and Immunity. 25:S137-S145.

Kane, C.J.M., K.D. Phelan, and P.D. Drew. 2012. Neuroimmune mechanisms in fetal alcohol spectrum disorder. Dev. Neurobiol. 72:1302-1316.

Kane, C.J.M., K.D. Phelan, J.C. Douglas, G. Wagoner, J. Walker-Johnson, J. Xu, and P.D. Drew. 2013. Effects of ethanol on immune response in the brain: region specific changes in aged mice. J. Neuroinflammation. 10:66-69.

Kane, C.J.M., K.D. Phelan, J.C. Douglas, G. Wagoner, J. Walker-Johnson, J. Xu, P.S. Phelan, and P.D. Drew. 2014. Effects of ethanol on immune response in the brain: region specific changes in adolescent versus adult mice. Alcohol Clin. Exp. Res. 38:384-391.

Drew, P.D., J.W. Johnson, J.C. Douglas, K.D. Phelan, and C.J.M. Kane. 2015. Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders. Alcohol Clin. Exp. Res. 39:445-454.

Kane, C.J.M., and P.D. Drew. 2016. Inflammatory Responses to Alcohol in the CNS: Nuclear Receptors as Potential Therapeutics for Alcohol-Induced Neuropathologies. Journal of Leukocyte Biology. 100:951-959.

Drew, P.D., and C.J.M. Kane. 2016. Peroxisome Proliferator-Activated Receptor-γ Agonists: Potential Therapeutics for Neuropathology Associated with Fetal Alcohol Spectrum Disorders. J. Clin. Cell. Immunol. 7: 469-474.

Cippitelli, A., E. Domi, M. Ubaldi, J.C. Douglas, H. W. Li, G. Demopulos, G. Gaitanaris, M. Roberto, P.D. Drew, C.J.M. Kane, and R. Ciccocioppo. 2017. Protection Against Alcohol-induced Neuronal and Cognitive Damage by the PPARγ Receptor Agonist  Pioglitazone. Brain Behavior Immunity. 64: 320-329.

Chen, J., J.L. Martindale, C. Cramer, M. Gorospe, U. Atasoy, P.D. Drew, and S. Yu. 2017. RNA-binding Protein HuR Deficiency Reduced CCR6 Expression on Th17 cells and ameliorated autoimmune neuroinflammation. J Biological Chemistry. 292:14532-14543.